| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8435737 | Cancer Letters | 2013 | 17 Pages |
Abstract
⺠We discuss the challenges presented by intra tumour heterogeneity (ITH). ⺠We present the current evidence for the existence of intra tumour heterogeneity and also some examples of its absence. ⺠We examine in detail the problems faced in calling point mutations and present some possible solutions. ⺠The implications of ITH on mechanisms underlying the acquisition of drug resistance are discussed.
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Authors
Stuart Horswell, Nicholas Matthews, Charles Swanton,