Article ID Journal Published Year Pages File Type
8435748 Cancer Letters 2014 8 Pages PDF
Abstract
This work describes the effects of elastin-like polypeptide (ELP) with the p21Waf1/Cip1-derived cell cycle inhibitory peptide (p21) on pancreatic tumor cells with gemcitabine. The thermo-responsive property of ELP permits use of a mild, local hyperthermia to target tumors for the transport of chemotherapeutics. In this study, a p21-ELP construct with Bac cell penetrating peptide was designed, and its anticancer activities in pancreatic cancer cell lines was examined. In combination with gemcitabine, the peptide demonstrated enhanced in vitro cytotoxicity as well as tumor growth inhibition in an animal model. Our data suggest that this ELP construct, with gemcitabine, may improve pancreatic cancer therapy.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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