Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8435765 | Cancer Letters | 2013 | 7 Pages |
Abstract
Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main aspects of current genomics research with its application in cancer topics. We will first overview the next-generation sequencing technologies, then outline the major computational approaches, particularly focusing on ChIP-based omics data, and list several remaining open questions facing computational biologists, further present regulatory network analysis inferred from the ChIP-based omics data; finally implicate the clinical outcomes from the network and pathway analysis.
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Authors
Binhua Tang, Pei-Yin Hsu, Tim H.-M. Huang, Victor X. Jin,