| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8437628 | EBioMedicine | 2018 | 11 Pages |
Abstract
Our findings demonstrate that the Ldlr KO hamster is an animal model of choice for human FH and has great potential in translational research of hyperlipidemia and coronary heart disease.
Keywords
CHDCETPapoBHDLPCSK9VLDLLPLHoFHLDLRHeFHCRISPR/Cas9AtherosclerosisApoeApolipoprotein Bapolipoprotein Ecoronary artery diseasechow dietCADLipoprotein lipasehigh density lipoproteinvery low density lipoproteinlow density lipoproteinLDLknockoutHyperlipidemiaHeterozygous familial hypercholesterolemiaFamilial hypercholesterolemiaHomozygous familial hypercholesterolemiacholesteryl ester transfer proteinProprotein convertase subtilisin/kexin type 9LDL receptorlow density lipoprotein receptor
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Authors
Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu,