| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8438298 | EBioMedicine | 2017 | 7 Pages |
Abstract
CFZ increased CPP, resting vasoconstricting tone and the spasmogenic effect of different agents. Preincubation with CFZ decreased the anti-spasmogenic activity of NTG and NFP, as well as reduced by over 50% the vasodilating effect of Ach, suggesting that CFZ can impair vasodilation via an endothelium dependent mechanism. Further studies are warranted to establish its clinical safety in patients with known CAD and prior history of coronary spasm.
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Authors
Carol Chen-Scarabelli, Giovanni Corsetti, Evasio Pasini, Francesco S. Dioguardi, Gagan Sahni, Jagat Narula, Mara Gavazzoni, Hemang Patel, Louis Saravolatz, Richard Knight, Riccardo Raddino, Tiziano M. Scarabelli,