Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8438336 | EBioMedicine | 2017 | 7 Pages |
Abstract
Ipratropium induces a larger bronchodilator response in female than in male patients and the benefits are particularly notable in non-obese females. Female lungs have greater gene expression for the M3 muscarinic receptor relative to M2 receptors than male lungs. Female patients are thus more likely to benefit from ipratropium than male COPD patients.
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Authors
Xuan Li, Ma'en Obeidat, Guohai Zhou, Janice M. Leung, Donald Tashkin, Robert Wise, John Connett, Philippe Joubert, Yohan Bossé, Maarten van den Berge, Corry-Anke Brandsma, David C. Nickle, Ke Hao, Peter D. Paré, Don D. Sin,