Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8438552 | EBioMedicine | 2017 | 10 Pages |
Abstract
EED is a syndrome characterized by secondary carnitine deficiency, abnormal fatty acid oxidation, alterations in polyphenol and amino acid metabolites, and metabolic dysregulation of sulfur amino acids, tryptophan, and the urea cycle. Future studies are needed to corroborate the presence of secondary carnitine deficiency among children with EED and to understand how these metabolic derangements may negatively affect the growth and development of young children.
Keywords
EEDTMAOS-adenosylhomocysteineSAHSAMROCRSDOCTN2LC-MS/MSUPLC-MS/MSAcylcarnitinesEnvironmental enteric dysfunctionS-adenosylmethioninerelative standard deviationFatty acid oxidationBAIBATrimethylamine-n-oxideTryptophanMass spectrometryLiquid chromatography-tandem mass spectrometryReceiver operating characteristic curveHippuratePolyphenolsUrea cycleCarnitine
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Authors
Richard D. Semba, Indi Trehan, Ximin Li, Ruin Moaddel, M. Isabel Ordiz, Kenneth M. Maleta, Klaus Kraemer, Michelle Shardell, Luigi Ferrucci, Mark Manary,