Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic Î² Cells during Fasting and in Type 2 Diabetes

Article ID	Journal	Published Year	Pages	File Type
8439021	EBioMedicine	2016	13 Pages	PDF

Keywords

SNS PNX GSIS Otsuka Long-Evans Tokushima Fatty Long-Evans Tokushima Otsuka IPITT OLETF FSIVGTT 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside OGTT GIP GLP-1 2-deoxy-d-glucose intracerebroventricular ICV AMPK 18F-FDG ACC AICAR SNPs 2-DG AMP-activated protein kinase HOMA-β intraperitoneal insulin tolerance test Oral glucose tolerance test acetyl coA carboxylase Sprague-Dawley Diabetes Insulin secretion Glucose-stimulated insulin secretion Frequently sampled intravenous glucose tolerance test computed tomography Positron emission tomography LETO Pancreatic β cell sympathetic nervous system SUV standardized uptake value AIR Acute insulin response PET Single nucleotide polymorphisms glucagon-like peptide-1 Starvation glucose-dependent insulinotropic polypeptide

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Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic Î² Cells during Fasting and in Type 2 Diabetes

Authors

Shinji Kume, Motoyuki Kondo, Shiro Maeda, Yoshihiko Nishio, Tsuyoshi Yanagimachi, Yukihiro Fujita, Masakazu Haneda, Keiko Kondo, Akihiro Sekine, Shin-ich Araki, Hisazumi Araki, Masami Chin-Kanasaki, Satoshi Ugi, Daisuke Koya, Sawako Kitahara,