Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8439137 | EBioMedicine | 2016 | 11 Pages |
Abstract
Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Ramapraba Appanna, Srinivasan KG, Mei Hui Xu, Ying-Xiu Toh, Sumathy Velumani, Daniel Carbajo, Chia Yin Lee, Roland Zuest, Thavamalar Balakrishnan, Weili Xu, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Yee Sin Leo, Tun Linn Thein, Cheng-I Wang,