Article ID Journal Published Year Pages File Type
8439312 European Journal of Cancer 2018 9 Pages PDF
Abstract
This study shows that radiotherapy and genotoxic chemotherapies significantly increase the risk of tumour development in a LFS mice model. These results strongly support the contribution of genotoxic anticancer treatments to MPC development in LFS patients. Therefore, to reduce the risk of MPCs in germline TP53 mutation carriers, radiotherapy should be avoided whenever possible, surgical treatment prioritised, and non-genotoxic treatments considered.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Authors
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