Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8439312 | European Journal of Cancer | 2018 | 9 Pages |
Abstract
This study shows that radiotherapy and genotoxic chemotherapies significantly increase the risk of tumour development in a LFS mice model. These results strongly support the contribution of genotoxic anticancer treatments to MPC development in LFS patients. Therefore, to reduce the risk of MPCs in germline TP53 mutation carriers, radiotherapy should be avoided whenever possible, surgical treatment prioritised, and non-genotoxic treatments considered.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Edwige Kasper, Emilie Angot, Elodie Colasse, Lionel Nicol, Jean-Christophe Sabourin, Sahil Adriouch, Yann Lacoume, Camille Charbonnier, Sabine Raad, Thierry Frebourg, Jean-Michel Flaman, Gaëlle Bougeard,