| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8440893 | European Journal of Cancer | 2016 | 8 Pages |
Abstract
Sunitinib uptake by platelets inhibits collagen receptor-induced aggregation and thrombus formation via reduction of protein tyrosine phosphorylation and α-granule secretion. This dysfunction may contribute to the higher bleeding tendency observed in sunitinib-treated patients.
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Authors
Siamack Sabrkhany, Arjan W. Griffioen, Sharo Pineda, Linda Sanders, Nadine Mattheij, Johanna P. van Geffen, Maureen J. Aarts, Johan W.M. Heemskerk, Mirjam G.A. oude Egbrink, Marijke J.E. Kuijpers,