Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8444336 | European Journal of Cancer | 2013 | 11 Pages |
Abstract
These data suggest that dose-finding studies might not be necessary for all the MTAs in children. Except in the case of a narrow therapeutic index, early-phase trials validating pharmacokinetics, pharmacodynamic markers and efficacy findings from adults while controlling for toxicity appear to be a possible alternative to accelerate drug development in paediatric oncology.
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Authors
Xavier Paoletti, Birgit Geoerger, François Doz, André Baruchel, François Lokiec, Christophe Le Tourneau,