Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8445198 | European Journal of Cancer | 2013 | 6 Pages |
Abstract
Nuclear Bag-1 was present in 80% of tumours. In 40% Bag-1 resided in the cytosol, which was almost exclusively associated with nuclear expression. Nuclear Bag-1 protein was identified as an independent factor predicting a favourable outcome following radical resection of pancreatic head cancer. Eighteen percent of patients with nuclear Bag-1 were recurrence free and alive 5Â years following surgery compared to none of the patients lacking expression. In periampullary cancer Bag-1 was not associated with outcome. In conclusion, Bag-1 was present in the majority of both pancreatic head- and periampullary cancers. However it was only identified as a discriminator of outcome in pancreatic head cancer.
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Authors
Jill A. van der Zee, Timo L.M. ten Hagen, Wim C.J. Hop, Herman van Dekken, Bilyana M. Dicheva, Ann L.B. Seynhaeve, Gerben A. Koning, Alexander M.M. Eggermont, Casper H.J. van Eijck,