Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8447412 | European Journal of Cancer | 2011 | 8 Pages |
Abstract
While our results do not support a standardisation of the definition of DLT, the inclusion of following specifications in its definition when relevant would reduce the heterogeneity observed across trials: (1) DLT assessment period, (2) absolute severity according to NCI CTCAE classification as well as severity relative to baseline status, (3) minimum duration of toxicity, (4) reversibility of toxicity within a certain period of time, and (5) necessity to delay treatment or to reduce dose-intensity.
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Authors
Christophe Le Tourneau, Albiruni R.A. Razak, Hui K. Gan, Simona Pop, Véronique Diéras, Patricia Tresca, Xavier Paoletti,