| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8450405 | Experimental Cell Research | 2018 | 9 Pages |
Abstract
Results confirmed the increased expression of several markers characteristic of EMT and invasiveness in lymph node metastatic cells, with a significant variability between individual samples. Irinotecan and oxaliplatin decreased migration activity of the cells and to the varying degree affected the expression of EMT and invasiveness markers. In conclusion, in CRC EMT is present in metastatic cells over a phenotypic continuum whose expression is altered heterogeneously upon irinotecan and oxaliplatin treatment.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Veronika Skarkova, Vera Kralova, Lukas Krbal, Petra Matouskova, Jiri Soukup, Emil Rudolf,