Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8450450 | Experimental Cell Research | 2018 | 30 Pages |
Abstract
Proposed model for PRP4-induced cofilin and MIIP dephosphorylation and epithelial-mesenchymal transition (EMT) induction. PRP4 over-expression results in cofilin and MIIP dephosphorylation, causing actin dynamics to increase, which may lead to EMT. Another proposed pathway for EMT induction by dephosphorylated MIIP is illustrated in the black-dotted panel. MIIP may inhibit the Rac1 signaling pathway through PAK1 (Rac1 downstream target) binding competition, which results in reduced lamellipodia formation and, finally, EMT.189
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Authors
Salman Ul Islam, Muhammad Bilal Ahmed, Su Jin Lee, Adeeb Shehzad, Jong Kyung Sonn, Oh-Shin Kwon, Young Sup Lee,