| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8450553 | Experimental Cell Research | 2018 | 10 Pages |
Abstract
Our findings demonstrated that NLCR3 could ameliorate colonic epithelial barrier integrity in diabetes mellitus in a TRAF6-dependent manner, and NLCR3 was stimulated by butyrate via binding GPR43 on colonic epithelial cells.
Keywords
NF-κBNLRC3NLRsGPR109AGPR43PRRsNLRP3ZO-1T2DMTRAF6C57TEERSCFAsqRT-PCRDABGAPDHshRNAPBSNODLPSC57BL/6Jshort hairpin RNATLRsShort-chain fatty acidsmicrobe-associated molecular patternsTemButyratenucleotide-binding oligomerization domaindb/dbDiabetes mellitusType 2 diabeteszonula occludens 1TNF receptor-associated factor 6nuclear factor kappa BlipopolysaccharideMAMPSIntestinal barrierstimulator of interferon genesPhosphate-buffered salinetransepithelial electrical resistanceTransmission electron microscopySTINGquantitative real-time PCRglyceraldehyde-3-phosphate dehydrogenasepattern recognition receptorsToll-like receptors
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Authors
Di Cheng, Ji-Hao Xu, Jie-Yao Li, Si-Yi Wang, Ting-Feng Wu, Qi-Kui Chen, Tao Yu,