| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8452647 | Experimental Hematology | 2018 | 19 Pages |
Abstract
- Epigenetic (embryos) and genetic (aging) mechanisms generate multiple hematopoietic stem cell (HSC) clones.
- Aging reduces the number of active HSC clones.
- Old HSC clones have lower self-renewal and skewed myeloid differentiation potential.
- Environmental and genetic insults can cooperatively initiate blood cancer.
- Environmental insults may provide proliferative advantages to malignant HSCs.
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Authors
Anna Rita Migliaccio,