| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8452654 | Experimental Hematology | 2018 | 39 Pages |
Abstract
- Blockade of plasma placental growth factor (PlGF) in sickle cell disease (SCD) mice decreases plasma pro-inflammatory biomarker levels.
- Blockade of PlGF in SCD mice reduces plasma lactate dehydrogenase levels and organ congestion.
- Blockade of PlGF in SCD mice reduces vascular stasis in the dorsal skinfold chamber model.
- Blockade of PlGF is a potential therapeutic approach for SCD.
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Authors
Jian-Ming Gu, Shujun Yuan, Derek Sim, Keith Abe, Perry Liu, Martin Rosenbruch, Peter Bringmann, Katalin Kauser,