Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8453505 | Leukemia Research Reports | 2018 | 6 Pages |
Abstract
We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, pâ¯=â¯0.38) respectively. Leukocytosisâ¯â¥â¯20â¯Ãâ¯109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Passant Badr, Ghada M Elsayed, Dalia Negm Eldin, Bahia Y Riad, Nayera Hamdy,