Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8453528 | Leukemia Research Reports | 2018 | 4 Pages |
Abstract
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylprednisolone monotherapy, calcitriol increases methylprednisolone induced apoptosis dose-dependently (1.37-1.92-fold; pâ¯<â¯0.05). Pre-incubation with calcitriol increases the apoptotic effect of MK-2206 even further (3.6-fold; pâ¯<â¯0.05). It also potentiates synergism between MK-2206 and methylprednisolone (vehicle control 38% vs. calcitriol 58%, pâ¯<â¯0.01). The combination of calcitriol and AKT inhibition should be investigated further as treatment options for steroid resistance in T-ALL.
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Authors
Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert Hoepner,