| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8453866 | Lung Cancer | 2018 | 11 Pages |
Abstract
Our results provide evidence that the Fgf9-induced lung adenocarcinoma is associated with recruitment and activation of M2-biased TAMs, which provided multiple means of support to the tumor. This model represents an excellent means to further study the complex interactions between TAMs, their related chemokines, and progression of lung adenocarcinoma, and adds further evidence to support the importance of TAMs in tumorigenesis.
Keywords
Surfactant protein-CCAFFGF9CFESFTPCWLCMDSCEGFRBALFGFAdenocarcinomacolony-forming efficiencyTAMTumor associated macrophagesdouble transgenicLungNSCLCNon-small cell lung cancermyeloid-derived suppressor cellEndothelial cellsfibroblast growth factorCancer-associated fibroblastsbronchoalveolar lavageTumor-associated macrophageswild typeEpidermal growth factor receptor
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Authors
Ahmed E. Hegab, Mari Ozaki, Shizuko Kagawa, Junko Hamamoto, Hiroyuki Yasuda, Katsuhiko Naoki, Kenzo Soejima, Yongjun Yin, Tomonari Kinoshita, Tomonori Yaguchi, Yutaka Kawakami, David M. Ornitz, Tomoko Betsuyaku,