Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status

Article ID	Journal	Published Year	Pages	File Type
8454410	Lung Cancer	2017	11 Pages	PDF

Abstract

The genetic association of IL-6 rs2069840 with EGFR mutant lung adenocarcinoma was ascertained. In the discovery stage, haplotype GGG in three SNPs (rs2069840, rs2069852, rs2066992) of IL-6, synergetic effects of IL-6 rs2069840 and environmental tobacco smoke in the workplace were found to be related to EGFR mutant lung adenocarcinoma. ERCC2 rs238406 showed a marginally significant association with EGFR mutant lung adenocarcinoma in the validation stage (PÂ =Â 0.096). ERCC2 rs50871 and ATM rs611646 showed significant association with EGFR wild-type lung adenocarcinoma in the discovery stage. In conclusion, IL-6 rs2069840 conferred susceptibility to EGFR mutant lung adenocarcinoma in a Hong Kong and Macau never-smoking Chinese population.

Keywords

cross-validation consistency CVC HWE MDR ADC TKI EGFR FDR SNPs AIC MAF CHS CHB NER ALK standard deviation Functional significance Hardy-Weinberg equilibrium gene-environment interaction nucleotide excision repair Epidermal growth factor receptor mutation lung adenocarcinoma NSCLC Non-small cell lung cancer Linkage disequilibrium minor allele frequency Anaplastic lymphoma kinase Genome-wide association studies GWAS Akaike information criterion Tyrosine-kinase inhibitor false discovery rate Never-smokers Single nucleotide polymorphisms Single-nucleotide polymorphisms Multifactor dimensionality reduction Epidermal growth factor receptor