Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8454807 | Lung Cancer | 2015 | 27 Pages |
Abstract
Here, we report on a 31 years old female patient with an aggressively growing tumor localized in the median line that was initially sampled by endobronchial ultrasound-guided transbronchial biopsies. Pathological assessment of the biopsy specimens revealed a NUT carcinoma with typical morphological characteristics and an uncommon NUT translocation variant with a NSD3-NUT fusion. Diagnosis was further confirmed in the subsequent resection specimen. We describe specific clinical, histomorphological, and molecular characteristics of this tumor and provide a comprehensive review of the current literature on these rare neoplasms.
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Authors
Alexander Harms, Esther Herpel, Nicole Pfarr, Roland Penzel, Claus-Peter Heussel, Felix J.F. Herth, Hendrik Dienemann, Wilko Weichert, Arne Warth,