| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8454867 | Lung Cancer | 2015 | 28 Pages |
Abstract
The cobas® EGFR Mutation Test and BEAMing dPCR demonstrate a high sensitivity for T790M mutation detection. Genomic heterogeneity of T790M-mediated resistance may explain the reduced specificity observed with plasma-based detection of T790M mutations versus tissue. These data support the use of both platforms in the AZD9291 clinical development program.
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Authors
Kenneth S. Thress, Roz Brant, T. Hedley Carr, Simon Dearden, Suzanne Jenkins, Helen Brown, Tracey Hammett, Mireille Cantarini, J. Carl Barrett,