Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8454989 | Matrix Biology | 2018 | 35 Pages |
Abstract
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system.
Keywords
ECMCXCLPDGFCCLTGFNG2NGFHSPG2BMP1CSPG4FGFIPFPI3Kα-SMASMCEGFHSCMMPMAPKSTATneural/glial antigen 2Apoeapolipoprotein EinterleukinCOPDChronic obstructive pulmonary diseasetransforming growth factorHepatic stellate cellSmooth muscle cellKeratan sulfateDermatan sulfateSulfataseepidermal growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorneural growth factorfibroblast growth factorphosphatase and tensin homologFibrosislow density lipoproteinLDLCXC chemokine ligandCC chemokine ligandExtracellular matrixmatrix metalloproteinaseSignal transducer and activator of transcriptionPRELPHeparan sulfateperlecanProteoglycanmitogen-activated protein kinasePtenChondroitin sulfatechondroitin sulfate proteoglycan 4sulf
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Authors
Megan S. Lord, Fengying Tang, Jelena Rnjak-Kovacina, James G.W. Smith, James Melrose, John M. Whitelock,