Role of immune cells in crystal-induced kidney fibrosis

Article ID	Journal	Published Year	Pages	File Type
8455004	Matrix Biology	2018	32 Pages	PDF

Abstract

Chronic kidney diseases can lead to kidney fibrosis, which can be considered a futile attempt of tissue healing to replaces functional kidney tissue with connective tissue, basically forming a scar. Chronic inflammation is a frequent cause of kidney fibrosis. Classical as well as recently discovered immune cell subsets and their molecular mediators have been intensively investigated for their contribution to kidney fibrosis and their potential as therapeutic targets. Here we review the current knowledge about the role of immune cells in crystal-induced renal fibrosis.

Keywords

ILCs Tregs GRHPR CGN DCs glyoxylate reductase/hydroxypyruvate reductase UUO TEC MMP-9 UTI NLRP3 Ripk3 PRRs AKI MSU DAMPs MDSCs iNKT ECM natural killer MPO IRI NETs ROS TLRs Ischemia-reperfusion injury acute kidney injury alanine-glyoxylate aminotransferase NLRP3 inflammasome inflammation Chronic kidney diseases ESRD یا end stage renal disease neutrophil extracellular traps danger associated molecular patterns T regulatory cells Dendritic cells Myeloid derived suppressor cells tubular epithelial cells Innate lymphoid cells urinary tract infection invariant natural killer T Kidney fibrosis Extracellular matrix Matrix metalloproteinase-9 Toll like receptors end stage renal disease Monosodium urate CKD AGT Primary hyperoxaluria crystal nephropathy Crescentic glomerulonephritis Reactive oxygen species pattern recognition receptors