Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction

TUNEL-positive nuclei in the midgut of the col4a1DTS-L3 temperature-sensitive mutant (A) compared with wild-type animals (B); antimicrobial peptide overexpression in the mutant while wild-type animals are underexressing upon heat-shock (B); intestinal dysfunction demonstrated by the leakage of the food dye into hemolymph (E) compared with wild-type animals (D).82