Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8455618 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2018 | 6 Pages |
Abstract
Hearing and balance disorders are related to the inner ear and are among the major cause of falls in older adults. Hearing loss that commonly occurs with aging (aka presbyacusis) can result from noise exposure, smoking, ototoxic drugs and genetic factors such as mutations in nuclear and mitochondrial genes. Mutations in mitochondrial DNA (mtDNA) have been reported to play an important role in cell function by providing energy, as well as, cell death (apoptosis). This study aims to systematically review mitochondrial mutations associated with presbyacusis and suggests preventive measurements to improve the quality of life in older adults.
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Authors
Iman Ibrahim, Mev Dominguez-Valentin, Bernard Segal, Anthony Zeitouni, Sabrina Daniela da Silva,