Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8455708 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2015 | 9 Pages |
Abstract
Explicit models incorporating effects of genomic instability were developed and applied to the hemangioma cohort. It was found that a radiation-induced transition towards genomic instability was highly significant. The models indicate that the main effect of radiation-induced genomic instability is to increase the rate of transition of non-initiated cells to initiated cells with a proliferative advantage. The magnitude of such an acceleration cannot be inferred from epidemiological data alone, but must be complemented by radiobiological measurements.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Markus Eidemüller, Erik Holmberg, Peter Jacob, Marie Lundell, Per Karlsson,