Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction

Article ID	Journal	Published Year	Pages	File Type
8455765	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis	2014	8 Pages	PDF

Abstract

- A subtype of micronuclei (MN) is preferentially induced by oxidative stress.
- Induction of MN subtype by p53 dysfunction is mediated by oxidative stress.
- Oxidative and replication stresses reinforce each other in generating MN.

Keywords

p53 NAC DSBs MSF N-acetylcysteine ROS Hydrogen peroxide Genomic instability Oxidative stress Replication stress micronuclei double-strand breaks H2O2 Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research

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Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction

Authors

Bing Xu, Wenxing Wang, Haiyang Guo, Zhaoliang Sun, Zhao Wei, Xiyu Zhang, Zhaojian Liu, Jay A. Tischfield, Yaoqin Gong, Changshun Shao,