| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8455772 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2014 | 8 Pages |
Abstract
- Human CYP2E1 activates benzene and phenol for eukaryotic micronuclei (MN) induction.
- CYP2E1 activates hydroquinone (HQ) and catechol (CAT) for increased cytotoxicity.
- CYP2E1 activates HQ, CAT and 1,2,4-trihydroxybenzene (THB) for stronger MN induction.
- CYP2E1 may catalyze oxidation of the OH groups of HQ, CAT and THB.
- Human SULT1A1 reduces the genotoxicity of HQ, CAT and THB.
Keywords
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Authors
Hao Jiang, Yanmei Lai, Keqi Hu, Qinzhi Wei, Yungang Liu,