Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8455782 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2014 | 12 Pages |
Abstract
In conclusion, numerous processes and pathways deregulated in response to EOMs suggest a significant role of activated AhR. Interestingly, we did not observe substantial gene expression changes related to DNA damage response, possibly due to the antagonistic effect of non-genotoxic EOM components. Moreover, a comparison of EOM effects with other available data on modulation of global gene expression suggests possible overlap among the effects of PM2.5, EOMs and various types of AhR agonists.
Keywords
CyPWntcRNAPLPTLRTCDDNLRDEPNFkBRT-qPCRA549EOMc-PAHPAHPM2.5PBSAHRReverse transcription quantitative real-time PCRNODDMEMTGF-βFBSB[a]PcDNADMSOComplementary DNADulbecco's modified Eagle's mediumcomplementary RNAROSAh receptorBenzo[a]pyreneTransforming Growth Factor BetaEMTToll-like receptornucleotide-binding oligomerization domainKEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and GenomesDimethyl sulfoxideDiesel exhaust particlesRINfetal bovine serumA549 cellsCytochrome P450RNA Integrity Numbernuclear factor kappa BHuman embryonic lung fibroblastslactate dehydrogenaseLDHExtractable organic matterPhosphate-buffered salineBMPPolycyclic aromatic hydrocarbonPAHsbone morphogenetic proteinsGene expression profilepyridoxal-5′-phosphatehigh performance liquid chromatographyHPLCEpithelial–mesenchymal transitionReactive oxygen speciesNod-like receptoraryl hydrocarbon receptor
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Authors
Helena LÃbalová, Simona KrÄková, KateÅina UhlÃÅová, JiÅà Kléma, Miroslav Ciganek, Pavel Jr., Radim J. Å rám, Jan VondráÄek, Miroslav Machala, Jan Topinka,