Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8455786 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2014 | 8 Pages |
Abstract
In the present study, we confirmed the role that oxidative stress plays in the disease damaging lipids of cell membrane and, most importantly, causing genomic damage in circulating white blood cells of affected adolescents. This also indicates that oxidative stress can affect several tissues in the body. However, although the observed DNA damage is a clear indication that the proper DNA repair mechanisms are activated, the risk for young T1DM subjects of developing not only cardiovascular complications but also some type of cancer cannot be ruled out. In this view, females, probably due to hormonal imbalance typical of adolescence, might represent a more susceptible population.
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Authors
Caterina Giovannini, Simona Piaggi, Giovanni Federico, Roberto Scarpato,