Enhanced DNA repair of bleomycin-induced 3â²-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells

Article ID	Journal	Published Year	Pages	File Type
8455811	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis	2014	7 Pages	PDF

Abstract

- Repair of bleomycin damage was examined on a genome-wide scale.
- Bleomycin damage repair was enhanced at actively transcribed genes.
- Repair of the 3â²-phosphoglycolate termini produced by bleomycin was examined.
- Bleomycin repair was different on the sense and antisense strands of DNA.

Keywords

TSS TCr Tyrosyl-DNA phosphodiesterase 1 APE1 TDP1 PNKP apurinic/apyrimidinic endonuclease 1 DNA damage Bleomycin Transcription-coupled repair Next-generation sequencing transcription start site transcription coupled repair Phosphoglycolate