DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system

Article ID	Journal	Published Year	Pages	File Type
8455859	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis	2013	10 Pages	PDF

Abstract

DNA-protein crosslinks (DPCs)are processed by nucleotide excision repair (NER) and homologous recombination (HR) with base preference. The presence of NER may impede DPCs at AT pairs processed by HR.

Keywords

DPC DNA–protein crosslink transcription-coupled NER O6-Alkylguanine-DNA alkyltransferase hAGT TC-NER DNA–protein crosslinks oligodeoxyribonucleotide RNAP rpoB Hprt E. coli PMSF BER MGMT TLS DSB BDO DBE DTT GSH 1,2-Dibromoethane NER RNA polymerase Escherichia coli SDS-PAGE polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate oligo Cho Chinese Hamster Ovary nucleotide excision repair base excision repair dithiothreitol Rifampicin resistance translesion synthesis double-strand break phenylmethylsulfonyl fluoride Homologous recombination hypoxanthine phosphoribosyltransferase polymerase chain reaction PCR Molecular weight Glutathione

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DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system

Authors

Qingming Fang,