Article ID Journal Published Year Pages File Type
8455867 Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2013 8 Pages PDF
Abstract
► Irinotecan (CPT-11) shows concentrations-dependent cytotoxicity in SW620 cells. ► Higher concentrations of CPT-11 induce massive p38 activity resulting in mitochondrial caspase-mediated apoptosis. ► Lower concentrations of CPT-11 induce lower but longer lasting p38 activity with suppressed apoptosis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells
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