Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E

Article ID	Journal	Published Year	Pages	File Type
8455887	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis	2012	10 Pages	PDF

Abstract

âº MDS improves the computational prediction accuracy of deleterious SNPs. âº Computationaly predicted deleterious SNP lies in CENP-E motor domain. âº Structural and functional impact of predicted SNP on CENP-E motor domain.

Keywords

RMSD MDS RMSF Non-synonymous single nucleotide polymorphisms CENP-E Root-mean square fluctuation Number of hydrogen bonds nsSNPs root-mean-square deviation SNP analysis SASA essential dynamics Cancer solvent-accessible surface area Molecular dynamics simulation Radius of gyration