| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8455891 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2012 | 7 Pages |
Abstract
⺠We have shown that merbarone is cytotoxic and genotoxic, it inhibited topo II catalytic activity, and induced endoreduplication in cultured CHO cells. ⺠We have shown using different novelty techniques, that merbarone effectively induces DNA damage per se. ⺠We have also shown that merbarone depends on ongoing DNA synthesis for its genotoxic effects.
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Authors
Nuria Pastor, Inmaculada DomÃnguez, Manuel LuÃs Orta, Claudia Campanella, Santiago Mateos, Felipe Cortés,