| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8455899 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2012 | 9 Pages |
Abstract
⺠Frameshifts observed with the SOSA method may lead to genetic mutations in vivo. ⺠Sulfolobus solfataricus Dpo4 is less error-prone than human Y-family DNA polymerases. ⺠Frameshift error frequency caused by Y-family enzymes increases in the presence of dGAP. ⺠hRev1 is the most suitable human Y-family enzyme to faithfully bypass dGAP. ⺠hPolκ is the most suitable human Y-family enzyme to faithfully extend dGAP bypass products.
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Authors
Shanen M. Sherrer, David J. Taggart, Lindsey R. Pack, Chanchal K. Malik, Ashis K. Basu, Zucai Suo,