Article ID Journal Published Year Pages File Type
8455901 Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2012 9 Pages PDF
Abstract
► Dpb2p, a noncatalytic subunit of Pol ɛ, influences the fidelity of DNA replication. ► Inactivation of DNA Pol ζ in dpb2 strains decreases the mutation rates by 30-50%. ► Mutated Dpb2p variants influence DNA Pol ɛ insertion fidelity.
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Preview
Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae
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