Role of damage-specific DNA polymerases in M13 phage mutagenesis induced by a major lipid peroxidation product trans-4-hydroxy-2-nonenal

Article ID	Journal	Published Year	Pages	File Type
8455957	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis	2012	11 Pages	PDF

Abstract

The results suggest that Pol V can infrequently bypass HNE-DNA adducts inducing mutations at G, C and A sites, while bypass by Pol IV and Pol II is error-free, but for Pol II infrequent.

Keywords

IPTG LPO DNA polymerase IV HNE MMS X-Gal DNA polymerase V o-nitrophenyl-β-d-galactoside ONPG 5-bromo-4-chloro-3-indolyl-β-d-galactoside Pol IV NER isopropyl-β-d-thiogalactopyranoside trans-4-Hydroxy-2-nonenal DNA repair mutations methyl methanesulfonate Lipid peroxidation Pol II Pol V

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Role of damage-specific DNA polymerases in M13 phage mutagenesis induced by a major lipid peroxidation product trans-4-hydroxy-2-nonenal

Authors

Beata Janowska, Dagmara Kurpios-Piec, Paulina Prorok, Grzegorz Szparecki, Marek Komisarski, PaweÅ Kowalczyk, Celina Janion, Barbara Tudek,