| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8455963 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2012 | 9 Pages |
Abstract
⺠Consumption of disinfected drinking water was associated to adverse health outcomes. ⺠Disinfection by-products are carcinogenic in animal models. ⺠Cyprinus carpio were exposed to drinking water in the presence of disinfectants. ⺠Modulation of liver cytochrome P450s and genotoxic effects were investigated. ⺠Water disinfection may be responsible of metabolism perturbation and DNA damage.
Keywords
AOXMRODNaClOHAAsPNHPRODClO2DBPsERODCyprinus carpioTrihalomethanesPAACyPTHMsAPNDTOCROSDrinking waterAminopyrine N-demethylaseethoxyresorufin O-deethylasePeracetic acidHaloacetic acidstestosterone hydroxylaseChlorine dioxideSodium hypochloriteCancerCytochrome P450Disinfection by-productsmethoxyresorufin O-demethylaseMicronucleusAdsorbable organic halogenstrihalomethane formation potentialpentoxyresorufin O-dealkylaseTotal organic carbonReactive oxygen species
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Authors
Donatella Canistro, Simone Melega, Dario Ranieri, Andrea Sapone, Bianca Gustavino, Monica Monfrinotti, Marco Rizzoni, Moreno Paolini,