| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456222 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2018 | 39 Pages |
Abstract
The data are intended to demonstrate the use of the 3D Skin Comet assay as a new in vitro tool for following up on positive findings from the standard in vitro genotoxicity test battery for dermally applied chemicals, ultimately helping to drive the regulatory acceptance of the assay. To expand the database, the validation will continue by testing an additional 22 chemicals.
Keywords
EURL-ECVAMMMSIn vitro genotoxicityLMABAPAPCOECDAdenylate kinaseEuropean Union Reference Laboratory for Alternatives to Animal TestingDNA damageaphidicolinlow melting agaroseAliBenzo[a]pyreneComet assayOrganization for Economic Co-operation and DevelopmentFull thicknessDermal exposureMethyl methane sulfonatetrue positivePrediction modeltrue negativeSkinSolvent controlPositive controlnegative control
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Authors
Kerstin Reisinger, Veronika Blatz, Joep Brinkmann, Thomas R. Downs, Anja Fischer, Frank Henkler, Sebastian Hoffmann, Cyrille Krul, Manfred Liebsch, Andreas Luch, Ralph Pirow, Astrid A. Reus, Markus Schulz, Stefan Pfuhler,