| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456362 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2015 | 11 Pages |
Abstract
The results indicated that 1,3-dichloropropene induced DNA damage only in liver cells at all three test article doses, while no effects were observed in the stomach and jejunum cells. Additionally, it did not increase MNPCEs in the bone marrow. 1,3-Dichloropropene was concluded to be negative in the MN assay but positive in the comet assay. Ethionamide did not induce DNA damage in liver. However, in stomach, statistically significant decreases (although still within historical range) in % tail DNA at all test article doses compared to the vehicle control were observed. There was no increase in MNPCEs in the bone marrow. Thus, ethionamide was concluded to be negative in the comet/MN combined assay. Busulfan did not induce DNA damage in any of the organs tested (liver and stomach) but it did induce a significant increase in MNPCEs in the bone marrow. Busulfan was concluded to be negative in the comet assay but positive in the MN assay.
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Authors
Kamala Pant, Ljubica Krsmanovic, Shannon Wilson Bruce, Tawney Kelley, Mirna Arevalo, Samuel Atta-Safoh, Fekadu Debelie, Michelle L. Klug La Force, Sandra Springer, Jamie Sly, Madhav Paranjpe, Timothy Lawlor, Marilyn Aardema,