| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456365 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2015 | 10 Pages |
Abstract
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay, we examined the ability of acrylonitrile, 9-aminoacridine hydrochloride monohydrate (9-AA), and ethanol to induce DNA damage in the liver and glandular stomach of male rats. Acrylonitrile is a genotoxic carcinogen, 9-AA is a genotoxic non-carcinogen, and ethanol is a non-genotoxic carcinogen. Positive results were obtained in the liver cells of male rats treated with known genotoxic compounds, acrylonitrile and 9-AA.
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Authors
Yuzuki Nakagawa, Tomoyasu Toyoizumi, Hajime Sui, Ryo Ohta, Fumiaki Kumagai, Kenji Usumi, Yoshiaki Saito, Kohji Yamakage,