Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8456422 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2015 | 4 Pages |
Abstract
In the first experiment (14-day study), MMS was administered per os to 6-week-old male Crl:CD (SD) rats every day for 14 days at a dose of 12.5, 25, or 50Â mg/kg/day. In the second experiment (28-day study), 6-week-old male SD rats were treated with MMS at 7.5, 15, or 30Â mg/kg/day for 28 days, because the highest dose used in the 14-day study (50Â mg/kg/day) caused mortality. Hepatocyte and bone marrow cell specimens were prepared on the day after the final dose. The frequency of micronucleated hepatocytes (MNHEPs) in the liver and that of micronucleated immature erythrocytes (MNIMEs) in the bone marrow were evaluated. Exposure to 50Â mg/kg/day MMS for 14 days resulted in an increased frequency of MNHEPs, but MMS had no effect on the frequency of MNHEPs in the rats exposed to the chemical for 28 days at doses up to 30Â mg/kg/day. MMS induced MNIMEs production at doses of 25 and 50Â mg/kg/day in the 14-day study and at doses of 15 and 30Â mg/kg/day in the 28-day study. Overall, the effect of MMS on the frequency of MNHEPs was considered to be equivocal.
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Authors
Shigeharu Muto, Katsuya Yamada, Tatsuya Kato, Yumi Wako, Kazufumi Kawasako, Yumiko Iwase, Yoshifumi Uno,