Fosfomycin increases chromosome instability in lymphocytes from Fanconi Anemia patients

Article ID	Journal	Published Year	Pages	File Type
8456534	Mutation Research/Genetic Toxicology and Environmental Mutagenesis	2013	5 Pages	PDF

Abstract

Results showed that FOM significantly increases CI in cultured lymphocytes from FA patients, compared to lymphocytes from HD, in which no effect was found. Additionally, a direct correlation between DEB and FOM toxicity was observed in lymphocytes from FA patients, indicating similar susceptibility to both agents.

Keywords

UDP-GlcNAc SmPC FOM GSH ICL PEP DEB ROS uridine diphosphate N-acetylglucosamine adenosine-5′-triphosphate ATP Healthy donors Chromosome instability Oxidative stress summary of product characteristics phosphoenolpyruvate Fosfomycin murA Interstrand crosslinks reduced glutathione Fanconi anemia Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research

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Fosfomycin increases chromosome instability in lymphocytes from Fanconi Anemia patients

Authors

Rosa Sousa, Filipa Ponte, Sara Teixeira, Lara Andrade, Cristina Gonçalves, José Barbot, Jorge Coutinho, Félix Carvalho, Beatriz Porto,