Article ID Journal Published Year Pages File Type
8456571 Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2012 13 Pages PDF
Abstract
► We examined the potential of gold and silica nanoparticles to cause genotoxic effects. ► Gold nanoparticles did not cause genotoxic effects in any of the assays. ► No effects were observed in the in vitro micronucleus assay with silica nanoparticles. ► Silica nanoparticles caused DNA damage in the in vivo Comet and micronucleus assays only at the MTD. ► Oxidative and inflammatory markers demonstrate tissue damage driven inflammation.
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Authors
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