| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456574 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2012 | 7 Pages |
Abstract
⺠Mice inhaled nanosized TiO2 anatase-brookite (0.8, 7.2, or 28.5 mg/m3) for 5 days. ⺠A dose-dependent deposition of Ti in lung tissue was seen. ⺠No increase in DNA damage was observed in lung epithelial cells. ⺠No induction of micronuclei was detected in blood polychromatic erythrocytes. ⺠A clear pulmonary neutrophilia was, however, present at 28.5 mg/m3 TiO2. ⺠Systemic TiO2 doses were much lower than in previous positive oral and i.p. studies.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Hanna K. Lindberg, Ghita C.-M. Falck, Julia Catalán, Antti J. Koivisto, Satu Suhonen, Hilkka Järventaus, Elina M. Rossi, Heli Nykäsenoja, Yrjö Peltonen, Carlos Moreno, Harri Alenius, Timo Tuomi, Kai M. Savolainen, Hannu Norppa,